BDBM50274198 3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2-methylpyrido[3,4-d]pyrimidin-4(3H)-one::CHEMBL521327

SMILES: Cc1nc2cnccc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1

InChI Key: InChIKey=AWUZLCXWWVAKEM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50274198 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2-me...) Show SMILES Cc1nc2cnccc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1 Show InChI InChI=1S/C23H26N4O2/c1-16-25-22-15-24-12-9-21(22)23(28)27(16)18-5-7-19(8-6-18)29-20-10-13-26(14-11-20)17-3-2-4-17/h5-9,12,15,17,20H,2-4,10-11,13-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274198 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2-me...) Show SMILES Cc1nc2cnccc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1 Show InChI InChI=1S/C23H26N4O2/c1-16-25-22-15-24-12-9-21(22)23(28)27(16)18-5-7-19(8-6-18)29-20-10-13-26(14-11-20)17-3-2-4-17/h5-9,12,15,17,20H,2-4,10-11,13-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair