BDBM50274200 3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-dimethyl-4(3H)-quinazolinone::CHEMBL484946
SMILES: Cc1cccc2nc(C)n(-c3ccc(OC4CCN(CC4)C4CCC4)cc3)c(=O)c12
InChI Key: InChIKey=LCORHUWUZKGEHY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50274200 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO-K1 cells | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50274200 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in HEK293 cells | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Mus musculus) | BDBM50274200 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-methylhistamine from mouse recombinant histamine H3 receptor | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50274200 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd... | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50274200 (3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-2,5-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT... | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
More data for this Ligand-Target Pair |