BDBM50274539 2-Methyl-3-[4-(4-piperidinyloxy)phenyl]-4(3H)-quinazolinone::CHEMBL449178

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCNCC2)cc1

InChI Key: InChIKey=SGUTYQRGKCLTRL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274539 (2-Methyl-3-[4-(4-piperidinyloxy)phenyl]-4(3H)-quin...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCNCC2)cc1 Show InChI InChI=1S/C20H21N3O2/c1-14-22-19-5-3-2-4-18(19)20(24)23(14)15-6-8-16(9-7-15)25-17-10-12-21-13-11-17/h2-9,17,21H,10-13H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair