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BDBM50274575 2-Methyl-3-(4-[(1-methyl-4-piperidinyl)oxy]phenyl)-4(3H)-quinazolinone::CHEMBL520800

SMILES: CN1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O

InChI Key: InChIKey=YBPLMSZYRHWSQS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274575   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50274575
PNG
(2-Methyl-3-(4-[(1-methyl-4-piperidinyl)oxy]phenyl)...)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O
Show InChI InChI=1S/C21H23N3O2/c1-15-22-20-6-4-3-5-19(20)21(25)24(15)16-7-9-17(10-8-16)26-18-11-13-23(2)14-12-18/h3-10,18H,11-14H2,1-2H3
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 740n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...


J Med Chem 51: 6889-901 (2008)


Article DOI: 10.1021/jm800569w
BindingDB Entry DOI: 10.7270/Q27P8Z60
More data for this
Ligand-Target Pair