new BindingDB logo
myBDB logout

BDBM50274579 3-(4-[(1-Isopropyl-4-piperidinyl)oxy]phenyl)-2-methyl-4(3H)-quinazolinone::CHEMBL519839

SMILES: CC(C)N1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O

InChI Key: InChIKey=PYTUDUDDLQDLRW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274579   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50274579
PNG
(3-(4-[(1-Isopropyl-4-piperidinyl)oxy]phenyl)-2-met...)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O
Show InChI InChI=1S/C23H27N3O2/c1-16(2)25-14-12-20(13-15-25)28-19-10-8-18(9-11-19)26-17(3)24-22-7-5-4-6-21(22)23(26)27/h4-11,16,20H,12-15H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...


J Med Chem 51: 6889-901 (2008)


Article DOI: 10.1021/jm800569w
BindingDB Entry DOI: 10.7270/Q27P8Z60
More data for this
Ligand-Target Pair