BDBM50274619 3-(4-[(1-Cyclobutyl-3-pyrrolidinyl)oxy]phenyl)-2-methyl-4(3H)-quinazolinone::CHEMBL485234

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCN(C2)C2CCC2)cc1

InChI Key: InChIKey=WIFJYCDZRGWRGW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274619 (3-(4-[(1-Cyclobutyl-3-pyrrolidinyl)oxy]phenyl)-2-m...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCN(C2)C2CCC2)cc1 Show InChI InChI=1S/C23H25N3O2/c1-16-24-22-8-3-2-7-21(22)23(27)26(16)18-9-11-19(12-10-18)28-20-13-14-25(15-20)17-5-4-6-17/h2-3,7-12,17,20H,4-6,13-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair