BDBM50274651 3-(4-[(1-Cyclopentyl-3-pyrrolidinyl)oxy]phenyl)-2-methyl-4(3H)-quinazolinone::CHEMBL521503

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCN(C2)C2CCCC2)cc1

InChI Key: InChIKey=WXHMKENPFHORLL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274651 (3-(4-[(1-Cyclopentyl-3-pyrrolidinyl)oxy]phenyl)-2-...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCN(C2)C2CCCC2)cc1 Show InChI InChI=1S/C24H27N3O2/c1-17-25-23-9-5-4-8-22(23)24(28)27(17)19-10-12-20(13-11-19)29-21-14-15-26(16-21)18-6-2-3-7-18/h4-5,8-13,18,21H,2-3,6-7,14-16H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair