BDBM50274690 CHEMBL521022::cis-2-Methyl-3-(4-([4-(1-pyrrolidinyl)cyclohexyl]oxy)phenyl)-4(3H)-quinazolinone

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@H](CC2)N2CCCC2)cc1

InChI Key: InChIKey=OXYRVSPLWYNARN-TYKWCNGQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50274690 (CHEMBL521022 | cis-2-Methyl-3-(4-([4-(1-pyrrolidin...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@H](CC2)N2CCCC2)cc1 |r,wU:17.18,20.25,(13.81,-35.86,;12.48,-36.64,;11.14,-35.87,;9.81,-36.65,;8.47,-35.89,;7.15,-36.66,;7.14,-38.2,;8.48,-38.97,;9.82,-38.2,;11.15,-38.96,;11.15,-40.5,;12.49,-38.19,;13.82,-38.95,;13.82,-40.49,;15.15,-41.26,;16.49,-40.49,;17.82,-41.25,;19.15,-40.47,;19.14,-38.94,;20.47,-38.17,;21.81,-38.94,;21.81,-40.48,;20.48,-41.25,;23.14,-38.16,;24.55,-38.79,;25.58,-37.64,;24.81,-36.31,;23.3,-36.63,;16.48,-38.94,;15.14,-38.18,)| Show InChI InChI=1S/C25H29N3O2/c1-18-26-24-7-3-2-6-23(24)25(29)28(18)20-10-14-22(15-11-20)30-21-12-8-19(9-13-21)27-16-4-5-17-27/h2-3,6-7,10-11,14-15,19,21H,4-5,8-9,12-13,16-17H2,1H3/t19-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274690 (CHEMBL521022 | cis-2-Methyl-3-(4-([4-(1-pyrrolidin...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@H](CC2)N2CCCC2)cc1 |r,wU:17.18,20.25,(13.81,-35.86,;12.48,-36.64,;11.14,-35.87,;9.81,-36.65,;8.47,-35.89,;7.15,-36.66,;7.14,-38.2,;8.48,-38.97,;9.82,-38.2,;11.15,-38.96,;11.15,-40.5,;12.49,-38.19,;13.82,-38.95,;13.82,-40.49,;15.15,-41.26,;16.49,-40.49,;17.82,-41.25,;19.15,-40.47,;19.14,-38.94,;20.47,-38.17,;21.81,-38.94,;21.81,-40.48,;20.48,-41.25,;23.14,-38.16,;24.55,-38.79,;25.58,-37.64,;24.81,-36.31,;23.3,-36.63,;16.48,-38.94,;15.14,-38.18,)| Show InChI InChI=1S/C25H29N3O2/c1-18-26-24-7-3-2-6-23(24)25(29)28(18)20-10-14-22(15-11-20)30-21-12-8-19(9-13-21)27-16-4-5-17-27/h2-3,6-7,10-11,14-15,19,21H,4-5,8-9,12-13,16-17H2,1H3/t19-,21+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair