BDBM50274691 CHEMBL485604::trans-2-Methyl-3-(4-([4-(1-pyrrolidinyl)cyclohexyl]oxy)phenyl)-4(3H)-quinazolinone

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@@H](CC2)N2CCCC2)cc1

InChI Key: InChIKey=OXYRVSPLWYNARN-XUTJKUGGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274691   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274691 (CHEMBL485604 | trans-2-Methyl-3-(4-([4-(1-pyrrolid...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@@H](CC2)N2CCCC2)cc1 |r,wU:17.18,wD:20.25,(33.03,-37.04,;31.7,-37.81,;30.36,-37.04,;29.03,-37.82,;27.69,-37.06,;26.36,-37.83,;26.36,-39.38,;27.7,-40.15,;29.03,-39.37,;30.37,-40.13,;30.37,-41.67,;31.71,-39.36,;33.04,-40.13,;33.04,-41.67,;34.37,-42.43,;35.71,-41.66,;37.04,-42.42,;38.37,-41.65,;38.35,-40.11,;39.69,-39.34,;41.03,-40.11,;41.03,-41.65,;39.7,-42.42,;42.36,-39.34,;43.76,-39.96,;44.79,-38.82,;44.02,-37.49,;42.52,-37.81,;35.7,-40.11,;34.36,-39.35,)| Show InChI InChI=1S/C25H29N3O2/c1-18-26-24-7-3-2-6-23(24)25(29)28(18)20-10-14-22(15-11-20)30-21-12-8-19(9-13-21)27-16-4-5-17-27/h2-3,6-7,10-11,14-15,19,21H,4-5,8-9,12-13,16-17H2,1H3/t19-,21-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	813	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair