BDBM50274712 CHEMBL515054::cis-5-(2-Aminocyclohexylamino)-7-(3-methoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

SMILES: COc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ccnc3c2C(N)=O)c1

InChI Key: InChIKey=QTQUGUWDCMAQRW-CABCVRRESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50274712 (CHEMBL515054 | cis-5-(2-Aminocyclohexylamino)-7-(3...) Show SMILES COc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ccnc3c2C(N)=O)c1 |r| Show InChI InChI=1S/C20H25N7O2/c1-29-13-6-4-5-12(11-13)24-18-16(17(22)28)19-23-9-10-27(19)20(26-18)25-15-8-3-2-7-14(15)21/h4-6,9-11,14-15,24H,2-3,7-8,21H2,1H3,(H2,22,28)(H,25,26)/t14-,15+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human ZAP70 expressed in Sf9 cells				Bioorg Med Chem 16: 9247-60 (2008) Article DOI: 10.1016/j.bmc.2008.09.015 BindingDB Entry DOI: 10.7270/Q2GM887N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50274712 (CHEMBL515054 | cis-5-(2-Aminocyclohexylamino)-7-(3...) Show SMILES COc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ccnc3c2C(N)=O)c1 |r| Show InChI InChI=1S/C20H25N7O2/c1-29-13-6-4-5-12(11-13)24-18-16(17(22)28)19-23-9-10-27(19)20(26-18)25-15-8-3-2-7-14(15)21/h4-6,9-11,14-15,24H,2-3,7-8,21H2,1H3,(H2,22,28)(H,25,26)/t14-,15+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of human Syk expressed in Sf9 cells				Bioorg Med Chem 16: 9247-60 (2008) Article DOI: 10.1016/j.bmc.2008.09.015 BindingDB Entry DOI: 10.7270/Q2GM887N
					More data for this Ligand-Target Pair