new BindingDB logo
myBDB logout

BDBM50274734 3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-6-fluoro-2-methyl-4(3H)-quinazolinone::CHEMBL517937

SMILES: Cc1nc2ccc(F)cc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1

InChI Key: InChIKey=WEWGUJCUGQFYMU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274734   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50274734
PNG
(3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-6-fl...)
Show SMILES Cc1nc2ccc(F)cc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C24H26FN3O2/c1-16-26-23-10-5-17(25)15-22(23)24(29)28(16)19-6-8-20(9-7-19)30-21-11-13-27(14-12-21)18-3-2-4-18/h5-10,15,18,21H,2-4,11-14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...


J Med Chem 51: 6889-901 (2008)


Article DOI: 10.1021/jm800569w
BindingDB Entry DOI: 10.7270/Q27P8Z60
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50274734
PNG
(3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-6-fl...)
Show SMILES Cc1nc2ccc(F)cc2c(=O)n1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C24H26FN3O2/c1-16-26-23-10-5-17(25)15-22(23)24(29)28(16)19-6-8-20(9-7-19)30-21-11-13-27(14-12-21)18-3-2-4-18/h5-10,15,18,21H,2-4,11-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...


J Med Chem 51: 6889-901 (2008)


Article DOI: 10.1021/jm800569w
BindingDB Entry DOI: 10.7270/Q27P8Z60
More data for this
Ligand-Target Pair