BDBM50274894 (Z)-5-(Naphthalen-1'-ylmethylene)-2-thioxothiazolidin-4-one::(Z)-5-(Naphthalen-1-ylmethylene)-2-thioxothiazolidin-4-one::CHEMBL457747
SMILES: SC1=NC(=O)C(S1)=Cc1cccc2ccccc12
InChI Key: InChIKey=KHWBBJGNDBRXEW-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Arylamine N-acetyltransferase 2 (Mus musculus) | BDBM50274894 ((Z)-5-(Naphthalen-1'-ylmethylene)-2-thioxothiazoli...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of mouse recombinant NAT2 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method | Bioorg Med Chem 17: 905-18 (2009) Article DOI: 10.1016/j.bmc.2008.11.032 BindingDB Entry DOI: 10.7270/Q2PZ58Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM50274894 ((Z)-5-(Naphthalen-1'-ylmethylene)-2-thioxothiazoli...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of recombinant PIM1 (unknown origin) by pyruvate kinase/lactate dehydrogenase-coupled assay | Bioorg Med Chem 25: 2657-2665 (2017) Article DOI: 10.1016/j.bmc.2017.02.056 BindingDB Entry DOI: 10.7270/Q2CV4M5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldose reductase (ALR2) (Bos taurus (Cattle)) | BDBM50274894 ((Z)-5-(Naphthalen-1'-ylmethylene)-2-thioxothiazoli...) | PDB GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Messina Curated by ChEMBL | Assay Description Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis | Bioorg Med Chem Lett 21: 200-3 (2010) Article DOI: 10.1016/j.bmcl.2010.11.041 BindingDB Entry DOI: 10.7270/Q2ZP46C4 | |||||||||||
More data for this Ligand-Target Pair |