BindingDB PrimarySearch

BDBM50275147 6-Gingerol::BDBM50317427::CHEMBL446043::GINGEROL::Gingerol::[6]-gingerol

SMILES: CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1

InChI Key: InChIKey=LPRPIMHDDACJHT-UHFFFAOYSA-N

Data: 1 KI 17 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50275147
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemistry and Applied Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting				Bioorg Med Chem 18: 3345-51 (2010) Article DOI: 10.1016/j.bmc.2010.02.062 BindingDB Entry DOI: 10.7270/Q2RN381W
					More data for this Ligand-Target Pair
Regulatory protein RhlR (Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Antagonist activity at Pseudomonas aeruginosa RhlR expressed in Escherichia coli DH5alpha incubated for 1.5 hrs by luminescence reporter gene assay				J Med Chem 63: 8388-8407 (2020)
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 m...				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Advanced Industrial Science and Technology (AIST) Curated by ChEMBL					Assay Description Inhibition of COX2				Bioorg Med Chem 16: 10332-7 (2008) Article DOI: 10.1016/j.bmc.2008.10.038 BindingDB Entry DOI: 10.7270/Q24M94C2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC4R)				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence a...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2B6 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 min...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC4R)				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...				Bioorg Med Chem Lett 27: 1826-1830 (2017) Article DOI: 10.1016/j.bmcl.2017.02.047 BindingDB Entry DOI: 10.7270/Q2VD71Q0
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Advanced Industrial Science and Technology (AIST) Curated by ChEMBL					Assay Description Inhibition of COX1				Bioorg Med Chem 16: 10332-7 (2008) Article DOI: 10.1016/j.bmc.2008.10.038 BindingDB Entry DOI: 10.7270/Q24M94C2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50275147 (6-Gingerol \| BDBM50317427 \| CHEMBL446043 \| GINGERO...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins pri...				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair