BDBM50275708 CHEMBL486737::N-(2-aminophenyl)-6-(7-(phenylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)nicotinamide

SMILES: Nc1ccccc1NC(=O)c1ccc(nc1)N1CCC2(CCN(C2)S(=O)(=O)c2ccccc2)C1

InChI Key: InChIKey=KPMJOTUARMGJAE-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50275708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50275708 (CHEMBL486737 | N-(2-aminophenyl)-6-(7-(phenylsulfo...) Show SMILES Nc1ccccc1NC(=O)c1ccc(nc1)N1CCC2(CCN(C2)S(=O)(=O)c2ccccc2)C1 Show InChI InChI=1S/C25H27N5O3S/c26-21-8-4-5-9-22(21)28-24(31)19-10-11-23(27-16-19)29-14-12-25(17-29)13-15-30(18-25)34(32,33)20-6-2-1-3-7-20/h1-11,16H,12-15,17-18,26H2,(H,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	2.85E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [35S]MK499 from human ERG expressed in HEK293 cells				Bioorg Med Chem Lett 18: 6104-9 (2008) Article DOI: 10.1016/j.bmcl.2008.10.052 BindingDB Entry DOI: 10.7270/Q23R0SQ2
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50275708 (CHEMBL486737 | N-(2-aminophenyl)-6-(7-(phenylsulfo...) Show SMILES Nc1ccccc1NC(=O)c1ccc(nc1)N1CCC2(CCN(C2)S(=O)(=O)c2ccccc2)C1 Show InChI InChI=1S/C25H27N5O3S/c26-21-8-4-5-9-22(21)28-24(31)19-10-11-23(27-16-19)29-14-12-25(17-29)13-15-30(18-25)34(32,33)20-6-2-1-3-7-20/h1-11,16H,12-15,17-18,26H2,(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human HDAC1 expressed in mammalian cells				Bioorg Med Chem Lett 18: 6104-9 (2008) Article DOI: 10.1016/j.bmcl.2008.10.052 BindingDB Entry DOI: 10.7270/Q23R0SQ2
					More data for this Ligand-Target Pair