BDBM50276065 (2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thiazol-4-yl)methanol::CHEMBL511811

SMILES: Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1

InChI Key: InChIKey=UPRPVDAEXQKBSI-UHFFFAOYSA-N

Data: 4 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50276065 ((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1 Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50276065 ((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1 Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ZAP70 (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50276065 ((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1 Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of SRC (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50276065 ((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1 Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2 (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50276065 ((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1 Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assay				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair