null

SMILES: CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1

InChI Key: InChIKey=MCAARVUCNCRTPF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H2 receptor (Homo sapiens (Human))	BDBM50276073 (CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...) Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8| Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	109	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50276073 (CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...) Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8| Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50276073 (CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...) Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8| Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	38.0	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50276073 (CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...) Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8| Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50276073 (CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...) Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1 |w:8.8| Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.64	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair