BDBM50277674 2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)propanamido)benzoic acid::CHEMBL482980

SMILES: OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21

InChI Key: InChIKey=FJMNOEYZTHLZFG-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50277674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50277674 (2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...) Show SMILES OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21 Show InChI InChI=1S/C20H16N2O5/c23-12-5-6-13-11(9-12)10-15-17(22-27-19(13)15)7-8-18(24)21-16-4-2-1-3-14(16)20(25)26/h1-6,9,23H,7-8,10H2,(H,21,24)(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP2C8 in human liver microsomes using montelukast substrate				J Med Chem 52: 2587-602 (2009) Article DOI: 10.1021/jm900151e BindingDB Entry DOI: 10.7270/Q2RJ4JDG
					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50277674 (2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...) Show SMILES OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21 Show InChI InChI=1S/C20H16N2O5/c23-12-5-6-13-11(9-12)10-15-17(22-27-19(13)15)7-8-18(24)21-16-4-2-1-3-14(16)20(25)26/h1-6,9,23H,7-8,10H2,(H,21,24)(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay				J Med Chem 52: 2587-602 (2009) Article DOI: 10.1021/jm900151e BindingDB Entry DOI: 10.7270/Q2RJ4JDG
					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50277674 (2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...) Show SMILES OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21 Show InChI InChI=1S/C20H16N2O5/c23-12-5-6-13-11(9-12)10-15-17(22-27-19(13)15)7-8-18(24)21-16-4-2-1-3-14(16)20(25)26/h1-6,9,23H,7-8,10H2,(H,21,24)(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]niacin from human GPR109A expressed in CHO cells				J Med Chem 52: 2587-602 (2009) Article DOI: 10.1021/jm900151e BindingDB Entry DOI: 10.7270/Q2RJ4JDG
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50277674 (2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...) Show SMILES OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21 Show InChI InChI=1S/C20H16N2O5/c23-12-5-6-13-11(9-12)10-15-17(22-27-19(13)15)7-8-18(24)21-16-4-2-1-3-14(16)20(25)26/h1-6,9,23H,7-8,10H2,(H,21,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes using diclofenac substrate				J Med Chem 52: 2587-602 (2009) Article DOI: 10.1021/jm900151e BindingDB Entry DOI: 10.7270/Q2RJ4JDG
					More data for this Ligand-Target Pair