BDBM50277873 CHEMBL485365::N-isopropyl-4-(3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine

SMILES: CC(C)Nc1nccc(n1)-c1cn[nH]c1C1CCCOC1

InChI Key: InChIKey=GTRPPGMPULGRCP-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50277873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50277873 (CHEMBL485365 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...) Show SMILES CC(C)Nc1nccc(n1)-c1cn[nH]c1C1CCCOC1 Show InChI InChI=1S/C15H21N5O/c1-10(2)18-15-16-6-5-13(19-15)12-8-17-20-14(12)11-4-3-7-21-9-11/h5-6,8,10-11H,3-4,7,9H2,1-2H3,(H,17,20)(H,16,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global R&D Curated by ChEMBL					Assay Description Inhibition of JNK1				Bioorg Med Chem Lett 19: 2099-102 (2009) Article DOI: 10.1016/j.bmcl.2009.03.023 BindingDB Entry DOI: 10.7270/Q26H4H9D
					More data for this Ligand-Target Pair