BindingDB PrimarySearch

BDBM50278344 CHEMBL470843::N-hydroxy-3-(4-(5-(morpholinomethyl)isoxazol-3-yl)phenyl)acrylamide hydrochloride

SMILES: ONC(=O)\C=C\c1ccc(cc1)-c1cc(CN2CCOCC2)on1

InChI Key: InChIKey=HMZAFAMGNRZJEH-ZZXKWVIFSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50278344
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 5 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC5				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC1				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC2				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC3				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC4				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC11				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC7				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC8				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC9				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC10				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50278344 (CHEMBL470843 \| N-hydroxy-3-(4-(5-(morpholinomethyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau SpA Curated by ChEMBL					Assay Description Inhibition of human HDAC6				Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2
R&D Sigma-Tau SpA Curated by ChEMBL					More data for this Ligand-Target Pair