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BDBM50278605 CHEMBL512858::N-(2-amino-1-phenylethyl)-4-cyclopropyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide

SMILES: NCC(NC(=O)c1cc(C2CC2)c(s1)-c1ccnc2[nH]ccc12)c1ccccc1

InChI Key: InChIKey=ZXAIWDLCJKVDIG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278605   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50278605
PNG
(CHEMBL512858 | N-(2-amino-1-phenylethyl)-4-cyclopr...)
Show SMILES NCC(NC(=O)c1cc(C2CC2)c(s1)-c1ccnc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C23H22N4OS/c24-13-19(15-4-2-1-3-5-15)27-23(28)20-12-18(14-6-7-14)21(29-20)16-8-10-25-22-17(16)9-11-26-22/h1-5,8-12,14,19H,6-7,13,24H2,(H,25,26)(H,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of AKT1


Bioorg Med Chem Lett 19: 2244-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.094
BindingDB Entry DOI: 10.7270/Q24X57PX
More data for this
Ligand-Target Pair