BDBM50278610 CHEMBL470012::N7-(3-chloro-4-fluorophenyl)-N2-(4-(2-morpholinoethyl)phenyl)thiazolo[4,5-d]pyrimidine-2,7-diamine

SMILES: Fc1ccc(Nc2ncnc3nc(Nc4ccc(CCN5CCOCC5)cc4)sc23)cc1Cl

InChI Key: InChIKey=YJCSNOSZBTYSKS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278610   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50278610 (CHEMBL470012 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...) Show SMILES Fc1ccc(Nc2ncnc3nc(Nc4ccc(CCN5CCOCC5)cc4)sc23)cc1Cl Show InChI InChI=1S/C23H22ClFN6OS/c24-18-13-17(5-6-19(18)25)28-21-20-22(27-14-26-21)30-23(33-20)29-16-3-1-15(2-4-16)7-8-31-9-11-32-12-10-31/h1-6,13-14H,7-12H2,(H2,26,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development LLC Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Bioorg Med Chem Lett 19: 2333-7 (2009) Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3
					More data for this Ligand-Target Pair