new BindingDB logo
myBDB logout

BDBM50278645 CHEMBL470202::N-(2-amino-1-phenylethyl)-4-(1H-pyrazol-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide

SMILES: NCC(NC(=O)c1cc(-c2cn[nH]c2)c(s1)-c1ccnc2[nH]ccc12)c1ccccc1

InChI Key: InChIKey=PUBMTSUNTTWJEJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278645   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50278645
PNG
(CHEMBL470202 | N-(2-amino-1-phenylethyl)-4-(1H-pyr...)
Show SMILES NCC(NC(=O)c1cc(-c2cn[nH]c2)c(s1)-c1ccnc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C23H20N6OS/c24-11-19(14-4-2-1-3-5-14)29-23(30)20-10-18(15-12-27-28-13-15)21(31-20)16-6-8-25-22-17(16)7-9-26-22/h1-10,12-13,19H,11,24H2,(H,25,26)(H,27,28)(H,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of AKT1


Bioorg Med Chem Lett 19: 2244-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.094
BindingDB Entry DOI: 10.7270/Q24X57PX
More data for this
Ligand-Target Pair