BDBM50278703 CHEMBL470391::N7-(3-ethynylphenyl)-N2-(4-(morpholinomethyl)phenyl)thiazolo[4,5-d]pyrimidine-2,7-diamine

SMILES: C#Cc1cccc(Nc2ncnc3nc(Nc4ccc(CN5CCOCC5)cc4)sc23)c1

InChI Key: InChIKey=VLZLKHGQUWVLCJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50278703 (CHEMBL470391 | N7-(3-ethynylphenyl)-N2-(4-(morphol...) Show SMILES C#Cc1cccc(Nc2ncnc3nc(Nc4ccc(CN5CCOCC5)cc4)sc23)c1 Show InChI InChI=1S/C24H22N6OS/c1-2-17-4-3-5-20(14-17)27-22-21-23(26-16-25-22)29-24(32-21)28-19-8-6-18(7-9-19)15-30-10-12-31-13-11-30/h1,3-9,14,16H,10-13,15H2,(H2,25,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development LLC Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Bioorg Med Chem Lett 19: 2333-7 (2009) Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3
					More data for this Ligand-Target Pair