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BDBM50278971 2-(5-(furan-2-carbonyl)-5,6-dihydrophenanthridin-6-yl)-2-oxoacetic acid::CHEMBL525412

SMILES: OC(=O)C(=O)C1N(C(=O)c2ccco2)c2ccccc2-c2ccccc12

InChI Key: InChIKey=ZWQXREYOFHXDLJ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278971   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50278971
PNG
(2-(5-(furan-2-carbonyl)-5,6-dihydrophenanthridin-6...)
Show SMILES OC(=O)C(=O)C1N(C(=O)c2ccco2)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H13NO5/c22-18(20(24)25)17-14-8-2-1-6-12(14)13-7-3-4-9-15(13)21(17)19(23)16-10-5-11-26-16/h1-11,17H,(H,24,25)
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair