BindingDB PrimarySearch

BDBM50279106 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one::5-(4-phenoxybutoxy)psoralen::CHEMBL444449

SMILES: O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1

InChI Key: InChIKey=KINMYBBFQRSVLL-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50279106
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay				Bioorg Med Chem Lett 19: 2299-304 (2009) Article DOI: 10.1016/j.bmcl.2009.02.077 BindingDB Entry DOI: 10.7270/Q29K4B38
4SC AG Curated by ChEMBL					More data for this Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4 (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
4SC AG Curated by ChEMBL					Assay Description Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay				Bioorg Med Chem Lett 19: 2299-304 (2009) Article DOI: 10.1016/j.bmcl.2009.02.077 BindingDB Entry DOI: 10.7270/Q29K4B38
4SC AG Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp				Eur J Med Chem 44: 1838-52 (2009) Article DOI: 10.1016/j.ejmech.2008.10.033 BindingDB Entry DOI: 10.7270/Q2QR4X5N
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human Kv1.3 ion channel expressed in CGE22 cells				Bioorg Med Chem Lett 20: 6989-92 (2010) Article DOI: 10.1016/j.bmcl.2010.09.131 BindingDB Entry DOI: 10.7270/Q2HD7VW2
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5 (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells				Bioorg Med Chem Lett 20: 6989-92 (2010) Article DOI: 10.1016/j.bmcl.2010.09.131 BindingDB Entry DOI: 10.7270/Q2HD7VW2
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subfamily A member 1/beta-1 (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method				Bioorg Med Chem Lett 22: 7106-9 (2012) Article DOI: 10.1016/j.bmcl.2012.09.080 BindingDB Entry DOI: 10.7270/Q2CV4JXW
Monash University (Parkville Campus) Curated by ChEMBL					More data for this Ligand-Target Pair