BDBM50279125 2-[1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-one::CHEMBL497879
SMILES: CN1C(=NC(=O)C1(C)C)c1nn(c(c1C)-c1ccc(cc1)C(F)(F)F)-c1ccc(Cl)cc1Cl
InChI Key: InChIKey=WVBRMLHZEWHOPM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50279125 (2-[1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-trifluoro...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from human recombinant CB1R expressed in HEK293 cells | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50279125 (2-[1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-trifluoro...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 81 | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Inverse agonist activity at human recombinant CB1R expressed in HEK293 cells assessed as inhibition of CP55940-stimulated Eu-GTP binding | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50279125 (2-[1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-trifluoro...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from human recombinant CB2R expressed in HEK293 cells | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair |