BDBM50279165 CHEMBL1203982::CHEMBL497724

SMILES: CNC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key: InChIKey=BLELPIAFNPVVPX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50279165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279165 (CHEMBL1203982 | CHEMBL497724) Show SMILES CNC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O2/c1-30-28(34)22-12-15-24-25(18-22)32-29(35)26(24)27(21-8-4-2-5-9-21)31-23-13-10-20(11-14-23)19-33-16-6-3-7-17-33/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,30,34)(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50279165 (CHEMBL1203982 | CHEMBL497724) Show SMILES CNC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O2/c1-30-28(34)22-12-15-24-25(18-22)32-29(35)26(24)27(21-8-4-2-5-9-21)31-23-13-10-20(11-14-23)19-33-16-6-3-7-17-33/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,30,34)(H,32,35)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL					Assay Description Inhibition of TGFbeta receptor				J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW
					More data for this Ligand-Target Pair