BDBM50279240 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1Hpyrazol-3-yl]-3,5,5-trimethyl-3,5-dihydro-imidazol-4-one::CHEMBL522904
SMILES: CCc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C1=NC(C)(C)C(=O)N1C
InChI Key: InChIKey=USNWJHORIWPSKG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50279240 (2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-e...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 33.8 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from human recombinant CB1R expressed in HEK293 cells | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50279240 (2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-e...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 65.5 | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Inverse agonist activity at human recombinant CB1R expressed in HEK293 cells assessed as inhibition of CP55940-stimulated Eu-GTP binding | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50279240 (2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from human recombinant CB2R expressed in HEK293 cells | J Med Chem 52: 4496-510 (2009) Article DOI: 10.1021/jm900471u BindingDB Entry DOI: 10.7270/Q26W99Z4 | |||||||||||
More data for this Ligand-Target Pair |