null
SMILES: O=C(Nc1ccncc1)c1cccnc1
InChI Key: InChIKey=HVLLFBPOFNSPRN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human)) | BDBM50279877 (CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 7.55E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent | Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu... | US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 [1-552] (Homo sapiens (Human)) | BDBM50279877 (CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 5.59E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
H. Lee Moffin Cancer Center and Research Institute, Inc. US Patent | Assay Description A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu... | US Patent US9409868 (2016) BindingDB Entry DOI: 10.7270/Q2X63KT0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50279877 (CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL | Assay Description Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assay | J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50279877 (CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL | Assay Description Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assay | J Med Chem 55: 2474-8 (2012) Article DOI: 10.1021/jm201289r BindingDB Entry DOI: 10.7270/Q2MG7QH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50279877 (CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | 2.12E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of angiotensin I phosphorylation catalyzed by the protein-tyrosine kinase p56 lck partially purified from bovine thymus. | Bioorg Med Chem Lett 1: 211-214 (1991) Article DOI: 10.1016/S0960-894X(00)80254-1 BindingDB Entry DOI: 10.7270/Q2H70FP1 | |||||||||||
More data for this Ligand-Target Pair |