BDBM50281519 CHEMBL124449::[3-Oxo-2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-aza-spiro[4.5]dec-(1Z)-ylidene]-acetic acid ethyl ester
SMILES: CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCCC1
InChI Key: InChIKey=FHQBYLLIOWHKRH-KQWNVCNZSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Angiotensin II type 1a (AT-1a) receptor (Bos taurus) | BDBM50281519 (CHEMBL124449 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem... | Bioorg Med Chem Lett 3: 369-374 (1993) Article DOI: 10.1016/S0960-894X(01)80914-8 BindingDB Entry DOI: 10.7270/Q20G3K2H | |||||||||||
More data for this Ligand-Target Pair |