BDBM50283470 2-(4-Chloro-phenylamino)-5H-[1,3]thiazino[5,4-b]indol-4-one::CHEMBL79118

SMILES: Oc1sc(Nc2ccc(Cl)cc2)nc2c1nc1ccccc21

InChI Key: InChIKey=OVGMBACFFHPZAJ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50283470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukocyte elastase (Homo sapiens (Human))	BDBM50283470 (2-(4-Chloro-phenylamino)-5H-[1,3]thiazino[5,4-b]in...) Show SMILES Oc1sc(Nc2ccc(Cl)cc2)nc2c1nc1ccccc21 Show InChI InChI=1S/C16H10ClN3OS/c17-9-5-7-10(8-6-9)18-16-20-13-11-3-1-2-4-12(11)19-14(13)15(21)22-16/h1-8,21H,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition of human leukocyte Elastase at 23 microM concentration from human polymorphonuclear leukocytes				Bioorg Med Chem Lett 4: 2399-2404 (1994) Article DOI: 10.1016/S0960-894X(01)80398-X BindingDB Entry DOI: 10.7270/Q2BZ65Z8
					More data for this Ligand-Target Pair