BDBM50285229 7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1,3]oxazolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione::CHEMBL303935

SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5ocnc5cc4cc3Cn1c2=O

InChI Key: InChIKey=CNLKOVNJMAVUSC-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50285229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50285229 (7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5ocnc5cc4cc3Cn1c2=O Show InChI InChI=1S/C21H15N3O5/c1-2-21(27)13-5-16-18-11(7-24(16)19(25)12(13)8-28-20(21)26)3-10-4-15-17(29-9-22-15)6-14(10)23-18/h3-6,9,27H,2,7-8H2,1H3/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formation				Bioorg Med Chem Lett 5: 2129-2132 (1995) Article DOI: 10.1016/0960-894X(95)00360-6 BindingDB Entry DOI: 10.7270/Q20Z7379
					More data for this Ligand-Target Pair