BDBM50285230 (S)-9-Amino-4-ethyl-4,8-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::CHEMBL67115

SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(O)c(N)cc4cc3Cn1c2=O

InChI Key: InChIKey=ZWCXMZVHJIJWHH-FQEVSTJZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50285230   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50285230 ((S)-9-Amino-4-ethyl-4,8-dihydroxy-1,12-dihydro-4H-...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(O)c(N)cc4cc3Cn1c2=O Show InChI InChI=1S/C20H17N3O5/c1-2-20(27)12-5-15-17-10(3-9-4-13(21)16(24)6-14(9)22-17)7-23(15)18(25)11(12)8-28-19(20)26/h3-6,24,27H,2,7-8,21H2,1H3/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formation				Bioorg Med Chem Lett 5: 2129-2132 (1995) Article DOI: 10.1016/0960-894X(95)00360-6 BindingDB Entry DOI: 10.7270/Q20Z7379
					More data for this Ligand-Target Pair