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BDBM50285328 CHEMBL285747::{[(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-ylcarbamoyl)-ethylamino]-methyl}-phosphonic acid

SMILES: OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)Nc1nnn[nH]1

InChI Key: InChIKey=GMJLDAOEGZAUDT-HNNXBMFYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50285328   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50285328
PNG
(CHEMBL285747 | {[(S)-2-Biphenyl-4-yl-1-(1H-tetrazo...)
Show SMILES OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C17H19N6O4P/c24-16(19-17-20-22-23-21-17)15(18-11-28(25,26)27)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15,18H,10-11H2,(H2,25,26,27)(H2,19,20,21,22,23,24)/t15-/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem
Article
n/an/a 1.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against neutral endopeptidase (NEP)


Bioorg Med Chem Lett 5: 145-150 (1995)


Article DOI: 10.1016/0960-894X(94)00474-T
BindingDB Entry DOI: 10.7270/Q2G160SW
More data for this
Ligand-Target Pair