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SMILES: COc1cc(C[C@H](NCP(O)(O)=O)c2nnn[nH]2)ccc1-c1ccccc1

InChI Key: InChIKey=ZHJIISVGMPTXTH-HNNXBMFYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50285340   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Rattus norvegicus (Rat))		BDBM50285340
PNG
(CHEMBL290285 | {[(S)-2-(2-Methoxy-biphenyl-4-yl)-1...)
Show SMILES COc1cc(C[C@H](NCP(O)(O)=O)c2nnn[nH]2)ccc1-c1ccccc1
Show InChI InChI=1S/C17H20N5O4P/c1-26-16-10-12(7-8-14(16)13-5-3-2-4-6-13)9-15(17-19-21-22-20-17)18-11-27(23,24)25/h2-8,10,15,18H,9,11H2,1H3,(H2,23,24,25)(H,19,20,21,22)/t15-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against neutral endopeptidase (NEP)

Bioorg Med Chem Lett 5: 145-150 (1995)


Article DOI: 10.1016/0960-894X(94)00474-T
BindingDB Entry DOI: 10.7270/Q2G160SW
More data for this
Ligand-Target Pair