Found 4 hits for monomerid = 50285557 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50285557
((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)Show SMILES [#6]-[#6]-[#6]-[#6]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C29H42N6O4/c1-3-4-9-21-13-15-22(16-14-21)17-18-25(33-20(2)28(38)39)27(37)35-24(12-8-19-32-29(30)31)26(36)34-23-10-6-5-7-11-23/h5-7,10-11,13-16,20,24-25,33H,3-4,8-9,12,17-19H2,1-2H3,(H,34,36)(H,35,37)(H,38,39)(H4,30,31,32)/t20-,24+,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human gelatinase-A (MMP-2) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50285557
((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)Show SMILES [#6]-[#6]-[#6]-[#6]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C29H42N6O4/c1-3-4-9-21-13-15-22(16-14-21)17-18-25(33-20(2)28(38)39)27(37)35-24(12-8-19-32-29(30)31)26(36)34-23-10-6-5-7-11-23/h5-7,10-11,13-16,20,24-25,33H,3-4,8-9,12,17-19H2,1-2H3,(H,34,36)(H,35,37)(H,38,39)(H4,30,31,32)/t20-,24+,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human stromelysin-3 (MMP-3) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50285557
((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)Show SMILES [#6]-[#6]-[#6]-[#6]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C29H42N6O4/c1-3-4-9-21-13-15-22(16-14-21)17-18-25(33-20(2)28(38)39)27(37)35-24(12-8-19-32-29(30)31)26(36)34-23-10-6-5-7-11-23/h5-7,10-11,13-16,20,24-25,33H,3-4,8-9,12,17-19H2,1-2H3,(H,34,36)(H,35,37)(H,38,39)(H4,30,31,32)/t20-,24+,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibition of MMP3 |
Bioorg Med Chem 15: 2223-68 (2007)
Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50285557
((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)Show SMILES [#6]-[#6]-[#6]-[#6]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C29H42N6O4/c1-3-4-9-21-13-15-22(16-14-21)17-18-25(33-20(2)28(38)39)27(37)35-24(12-8-19-32-29(30)31)26(36)34-23-10-6-5-7-11-23/h5-7,10-11,13-16,20,24-25,33H,3-4,8-9,12,17-19H2,1-2H3,(H,34,36)(H,35,37)(H,38,39)(H4,30,31,32)/t20-,24+,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human collagenase (MMP-1) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |