Found 4 hits for monomerid = 50285573 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50285573
((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C27H38N6O5/c1-3-38-21-14-11-19(12-15-21)13-16-23(31-18(2)26(36)37)25(35)33-22(10-7-17-30-27(28)29)24(34)32-20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22-23,31H,3,7,10,13,16-17H2,1-2H3,(H,32,34)(H,33,35)(H,36,37)(H4,28,29,30)/t18-,22+,23+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human gelatinase-A (MMP-2) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50285573
((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C27H38N6O5/c1-3-38-21-14-11-19(12-15-21)13-16-23(31-18(2)26(36)37)25(35)33-22(10-7-17-30-27(28)29)24(34)32-20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22-23,31H,3,7,10,13,16-17H2,1-2H3,(H,32,34)(H,33,35)(H,36,37)(H4,28,29,30)/t18-,22+,23+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 219 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibition of MMP3 |
Bioorg Med Chem 15: 2223-68 (2007)
Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50285573
((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C27H38N6O5/c1-3-38-21-14-11-19(12-15-21)13-16-23(31-18(2)26(36)37)25(35)33-22(10-7-17-30-27(28)29)24(34)32-20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22-23,31H,3,7,10,13,16-17H2,1-2H3,(H,32,34)(H,33,35)(H,36,37)(H4,28,29,30)/t18-,22+,23+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human stromelysin-3 (MMP-3) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50285573
((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6]-[#6@H](-[#7]-[#6@H](-[#6])-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c2ccccc2)cc1 Show InChI InChI=1S/C27H38N6O5/c1-3-38-21-14-11-19(12-15-21)13-16-23(31-18(2)26(36)37)25(35)33-22(10-7-17-30-27(28)29)24(34)32-20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22-23,31H,3,7,10,13,16-17H2,1-2H3,(H,32,34)(H,33,35)(H,36,37)(H4,28,29,30)/t18-,22+,23+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human collagenase (MMP-1) |
Bioorg Med Chem Lett 5: 2441-2446 (1995)
Article DOI: 10.1016/0960-894X(95)00425-S BindingDB Entry DOI: 10.7270/Q2D21XK6 |
More data for this Ligand-Target Pair | |