Found 4 hits for monomerid = 50286434 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Procathepsin L
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against cathepsin L |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this Ligand-Target Pair | |
Calpain1
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cathepsin B |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this Ligand-Target Pair | |
Calpain1
(Homo sapiens (Human)) | BDBM50286434
(1-(2-Chloro-4-hydroxy-phenyl)-4-oxo-7-pyridin-4-yl...)Show SMILES NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(ccc2c1=O)-c1ccncc1 Show InChI InChI=1S/C21H14ClN3O3/c22-17-10-14(26)2-4-18(17)25-11-16(21(23)28)20(27)15-3-1-13(9-19(15)25)12-5-7-24-8-6-12/h1-11,26H,(H2,23,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against human erythrocyte Calpain 1 |
Bioorg Med Chem Lett 5: 387-392 (1995)
Article DOI: 10.1016/0960-894X(95)00041-Q BindingDB Entry DOI: 10.7270/Q21G0M6W |
More data for this Ligand-Target Pair | |