BDBM50286485 5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(tetrahydro-pyran-4-yl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one::CHEMBL421899

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(C4CCOCC4)c(=O)c3cn(C3CC3)c2c1F

InChI Key: InChIKey=COESUPMZYQQHMA-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286485 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(C4CCOCC4)c(=O)c3cn(C3CC3)c2c1F Show InChI InChI=1S/C25H24F2N4O2/c1-13-9-15(10-14(2)28-13)21-20(26)11-18-23-19(12-30(16-3-4-16)24(18)22(21)27)25(32)31(29-23)17-5-7-33-8-6-17/h9-12,16-17H,3-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286485 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(C4CCOCC4)c(=O)c3cn(C3CC3)c2c1F Show InChI InChI=1S/C25H24F2N4O2/c1-13-9-15(10-14(2)28-13)21-20(26)11-18-23-19(12-30(16-3-4-16)24(18)22(21)27)25(32)31(29-23)17-5-7-33-8-6-17/h9-12,16-17H,3-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation.				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair