BDBM50286486 5-Cyclopropyl-2-(2-dimethylamino-ethyl)-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one::CHEMBL130381

SMILES: CN(C)CCn1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O

InChI Key: InChIKey=PGJDQMYHNOXAEZ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286486   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286486 (5-Cyclopropyl-2-(2-dimethylamino-ethyl)-7-(2,6-dim...) Show SMILES CN(C)CCn1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O Show InChI InChI=1S/C24H25F2N5O/c1-13-9-15(10-14(2)27-13)20-19(25)11-17-22-18(24(32)31(28-22)8-7-29(3)4)12-30(16-5-6-16)23(17)21(20)26/h9-12,16H,5-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286486 (5-Cyclopropyl-2-(2-dimethylamino-ethyl)-7-(2,6-dim...) Show SMILES CN(C)CCn1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O Show InChI InChI=1S/C24H25F2N5O/c1-13-9-15(10-14(2)27-13)20-19(25)11-17-22-18(24(32)31(28-22)8-7-29(3)4)12-30(16-5-6-16)23(17)21(20)26/h9-12,16H,5-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	930	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation.				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair