BDBM50286489 5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(4-methyl-cyclohexyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one::CHEMBL131600

SMILES: CC1CCC(CC1)n1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O

InChI Key: InChIKey=LFEWNSAKXIZYIJ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286489 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES CC1CCC(CC1)n1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O |(16.12,-2.01,;15.35,-3.34,;13.81,-3.34,;13.03,-4.69,;13.82,-6,;15.35,-6,;16.12,-4.69,;13.05,-7.35,;11.53,-7.5,;11.21,-9.01,;12.54,-9.78,;12.54,-11.32,;11.21,-12.09,;11.21,-13.63,;10.44,-14.98,;11.98,-14.96,;9.88,-11.32,;8.55,-12.09,;8.55,-13.63,;7.21,-11.32,;7.21,-9.78,;5.86,-9.01,;8.55,-9.01,;9.88,-9.78,;5.88,-12.09,;5.88,-13.63,;4.55,-14.4,;4.56,-15.94,;3.2,-13.63,;3.2,-12.09,;1.85,-11.3,;4.53,-11.32,;13.7,-8.73,;15.2,-9.05,)| Show InChI InChI=1S/C27H28F2N4O/c1-14-4-6-19(7-5-14)33-27(34)21-13-32(18-8-9-18)26-20(25(21)31-33)12-22(28)23(24(26)29)17-10-15(2)30-16(3)11-17/h10-14,18-19H,4-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286489 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES CC1CCC(CC1)n1nc2c(cn(C3CC3)c3c(F)c(c(F)cc23)-c2cc(C)nc(C)c2)c1=O |(16.12,-2.01,;15.35,-3.34,;13.81,-3.34,;13.03,-4.69,;13.82,-6,;15.35,-6,;16.12,-4.69,;13.05,-7.35,;11.53,-7.5,;11.21,-9.01,;12.54,-9.78,;12.54,-11.32,;11.21,-12.09,;11.21,-13.63,;10.44,-14.98,;11.98,-14.96,;9.88,-11.32,;8.55,-12.09,;8.55,-13.63,;7.21,-11.32,;7.21,-9.78,;5.86,-9.01,;8.55,-9.01,;9.88,-9.78,;5.88,-12.09,;5.88,-13.63,;4.55,-14.4,;4.56,-15.94,;3.2,-13.63,;3.2,-12.09,;1.85,-11.3,;4.53,-11.32,;13.7,-8.73,;15.2,-9.05,)| Show InChI InChI=1S/C27H28F2N4O/c1-14-4-6-19(7-5-14)33-27(34)21-13-32(18-8-9-18)26-20(25(21)31-33)12-22(28)23(24(26)29)17-10-15(2)30-16(3)11-17/h10-14,18-19H,4-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation.				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair