BDBM50286495 5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-[2-(2-hydroxy-ethylamino)-ethyl]-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one::CHEMBL133802

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(CCNCCO)c(=O)c3cn(C3CC3)c2c1F

InChI Key: InChIKey=UMYNSDJUTCOACR-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286495 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(CCNCCO)c(=O)c3cn(C3CC3)c2c1F Show InChI InChI=1S/C24H25F2N5O2/c1-13-9-15(10-14(2)28-13)20-19(25)11-17-22-18(12-30(16-3-4-16)23(17)21(20)26)24(33)31(29-22)7-5-27-6-8-32/h9-12,16,27,32H,3-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50286495 (5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c3nn(CCNCCO)c(=O)c3cn(C3CC3)c2c1F Show InChI InChI=1S/C24H25F2N5O2/c1-13-9-15(10-14(2)28-13)20-19(25)11-17-22-18(12-30(16-3-4-16)23(17)21(20)26)24(33)31(29-22)7-5-27-6-8-32/h9-12,16,27,32H,3-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation.				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair