BindingDB PrimarySearch

BDBM50286670 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphthalen-1-yl-piperazin-1-yl)-ethanone::CHEMBL160581

SMILES: NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12

InChI Key: InChIKey=FYCXANKHKYEXTR-UHFFFAOYSA-N

Data: 3 KI 8 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50286670
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	0.950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards dopaminergic (D2) receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards muscarinic (M) receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-1 (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards Alpha-1 adrenergic receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards histaminergic (H 1) receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenosine receptor A2b (Rattus norvegicus)	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards Alpha-2 adrenergic receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4) (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its affinity towards 5-hydroxytryptamine 4 receptor				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50286670 (2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	95	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in...				Bioorg Med Chem Lett 5: 663-666 (1995) Article DOI: 10.1016/0960-894X(95)00091-7 BindingDB Entry DOI: 10.7270/Q2ZK5GMX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair