BDBM50287332 1N-[4-cyclopropylmethyl-10-hydroxy-(13R,14R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yl]-2-chloroacrylamide::CHEMBL289426
SMILES: Oc1ccc2CC3C4CC[C@@H](NC(=O)C(Cl)=C)[C@@H]5Oc1c2C45CCN3CC1CC1
InChI Key: InChIKey=UDQTWCPWUCXLPN-CUUMVBPWSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50287332 (1N-[4-cyclopropylmethyl-10-hydroxy-(13R,14R)-12-ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for Inhibition of 9 (1nM) binding to Opioid receptor delta 1 from bovine striatal Membranes | Bioorg Med Chem Lett 6: 1563-1566 (1996) Article DOI: 10.1016/S0960-894X(96)00274-0 BindingDB Entry DOI: 10.7270/Q28P60GJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50287332 (1N-[4-cyclopropylmethyl-10-hydroxy-(13R,14R)-12-ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for Inhibition of [3H]-DPDPE (0.2 nM) binding to Opioid receptor kappa 1 from bovine striatal Membranes | Bioorg Med Chem Lett 6: 1563-1566 (1996) Article DOI: 10.1016/S0960-894X(96)00274-0 BindingDB Entry DOI: 10.7270/Q28P60GJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (CALF) | BDBM50287332 (1N-[4-cyclopropylmethyl-10-hydroxy-(13R,14R)-12-ox...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for Inhibition of [3H]-DAMGO (0.25 nM) binding to mu receptor from bovine striatal membranes | Bioorg Med Chem Lett 6: 1563-1566 (1996) Article DOI: 10.1016/S0960-894X(96)00274-0 BindingDB Entry DOI: 10.7270/Q28P60GJ | |||||||||||
More data for this Ligand-Target Pair |