BDBM50287944 (E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy]-1-phenyl-propenone::CHEMBL304637

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](O\C=C\C(=O)c2ccccc2)[C@@H](O)[C@H]1O

InChI Key: InChIKey=ZFCSVSGGFIXGSB-DQTLGYDPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287944   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase HRas (Homo sapiens (Human))	BDBM50287944 ((E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methy...) Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](O\C=C\C(=O)c2ccccc2)[C@@H](O)[C@H]1O Show InChI InChI=1S/C25H22ClN3O6/c1-13-19-20(26)16-12-15(33-2)8-9-17(16)27-23(19)29(28-13)24-21(31)22(32)25(35-24)34-11-10-18(30)14-6-4-3-5-7-14/h3-12,21-22,24-25,31-32H,1-2H3/b11-10+/t21-,22+,24-,25+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of nucleotide exchange process of oncogenic Ras in vitro				Bioorg Med Chem Lett 6: 195-200 (1996) Article DOI: 10.1016/0960-894X(95)00574-D BindingDB Entry DOI: 10.7270/Q2G160TB
					More data for this Ligand-Target Pair