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BDBM50287944 (E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy]-1-phenyl-propenone::CHEMBL304637

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](O\C=C\C(=O)c2ccccc2)[C@@H](O)[C@H]1O

InChI Key: InChIKey=ZFCSVSGGFIXGSB-DQTLGYDPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287944   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GTPase HRas


(Homo sapiens (Human))
BDBM50287944
PNG
((E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methy...)
Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](O\C=C\C(=O)c2ccccc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C25H22ClN3O6/c1-13-19-20(26)16-12-15(33-2)8-9-17(16)27-23(19)29(28-13)24-21(31)22(32)25(35-24)34-11-10-18(30)14-6-4-3-5-7-14/h3-12,21-22,24-25,31-32H,1-2H3/b11-10+/t21-,22+,24-,25+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of nucleotide exchange process of oncogenic Ras in vitro


Bioorg Med Chem Lett 6: 195-200 (1996)


Article DOI: 10.1016/0960-894X(95)00574-D
BindingDB Entry DOI: 10.7270/Q2G160TB
More data for this
Ligand-Target Pair