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BDBM50287946 1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-nitro-benzenesulfonyl)-morpholin-2-yl]-4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline::CHEMBL64328

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=KJKHKONBZRHHSR-SQJMNOBHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287946   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GTPase HRas


(Homo sapiens (Human))
BDBM50287946
PNG
(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C29H36ClN5O7SSi/c1-18-26-27(30)23-14-20(40-5)10-13-24(23)31-28(26)34(32-18)25-16-33(15-21(42-25)17-41-44(6,7)29(2,3)4)43(38,39)22-11-8-19(9-12-22)35(36)37/h8-14,21,25H,15-17H2,1-7H3/t21-,25+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of nucleotide exchange process of oncogenic Ras in vitro


Bioorg Med Chem Lett 6: 195-200 (1996)


Article DOI: 10.1016/0960-894X(95)00574-D
BindingDB Entry DOI: 10.7270/Q2G160TB
More data for this
Ligand-Target Pair