BDBM50287952 CHEMBL304717::N-{4-[(2S,6R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(4-chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-morpholine-4-sulfonyl]-phenyl}-acetamide

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(NC(C)=O)cc1

InChI Key: InChIKey=HFIYWZSTTKASLB-WNCULLNHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287952   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase HRas (Homo sapiens (Human))	BDBM50287952 (CHEMBL304717 | N-{4-[(2S,6R)-2-(tert-Butyl-dimethy...) Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C31H40ClN5O6SSi/c1-19-28-29(32)25-15-22(41-6)11-14-26(25)34-30(28)37(35-19)27-17-36(16-23(43-27)18-42-45(7,8)31(3,4)5)44(39,40)24-12-9-21(10-13-24)33-20(2)38/h9-15,23,27H,16-18H2,1-8H3,(H,33,38)/t23-,27+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of nucleotide exchange process of oncogenic Ras in vitro				Bioorg Med Chem Lett 6: 195-200 (1996) Article DOI: 10.1016/0960-894X(95)00574-D BindingDB Entry DOI: 10.7270/Q2G160TB
					More data for this Ligand-Target Pair