BDBM50287959 (E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitro-benzenesulfonyl)-morpholin-2-yl]-1-phenyl-but-2-en-1-one::CHEMBL304474

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@H](O1)C=CCC(=O)c1ccccc1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=NEIHTTLGPVTTPI-FUFSCUOVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase HRas (Homo sapiens (Human))	BDBM50287959 ((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...) Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@H](O1)C=CCC(=O)c1ccccc1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O |w:24.28| Show InChI InChI=1S/C32H28ClN5O7S/c1-20-30-31(33)26-17-23(44-2)13-16-27(26)34-32(30)37(35-20)29-19-36(46(42,43)25-14-11-22(12-15-25)38(40)41)18-24(45-29)9-6-10-28(39)21-7-4-3-5-8-21/h3-9,11-17,24,29H,10,18-19H2,1-2H3/t24-,29-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of nucleotide exchange process of oncogenic Ras in vitro				Bioorg Med Chem Lett 6: 195-200 (1996) Article DOI: 10.1016/0960-894X(95)00574-D BindingDB Entry DOI: 10.7270/Q2G160TB
					More data for this Ligand-Target Pair