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BDBM50287960 1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-nitro-benzenesulfonyl)-morpholin-2-yl]-4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline::CHEMBL304462

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)Sc1ccccc1[N+]([O-])=O

InChI Key: InChIKey=BVQARVWGGBGRSW-NBGIEHNGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287960   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
GTPase HRas


(Homo sapiens (Human))		BDBM50287960
PNG
(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)Sc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C29H36ClN5O5SSi/c1-18-26-27(30)21-14-19(38-5)12-13-22(21)31-28(26)34(32-18)25-16-33(41-24-11-9-8-10-23(24)35(36)37)15-20(40-25)17-39-42(6,7)29(2,3)4/h8-14,20,25H,15-17H2,1-7H3/t20-,25+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of nucleotide exchange process of oncogenic Ras in vitro

Bioorg Med Chem Lett 6: 195-200 (1996)


Article DOI: 10.1016/0960-894X(95)00574-D
BindingDB Entry DOI: 10.7270/Q2G160TB
More data for this
Ligand-Target Pair