BDBM50288961 1-(2-Biphenyl-4-yl-acetyl)-piperidine-4-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-mercaptomethyl-ethyl]-amide::CHEMBL345878

SMILES: SC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=VCQRCFTZJGFUNP-HHHXNRCGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50288961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human))	BDBM50288961 (1-(2-Biphenyl-4-yl-acetyl)-piperidine-4-carboxylic...) Show SMILES SC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2S/c35-30(18-22-10-12-24(13-11-22)23-6-2-1-3-7-23)34-16-14-25(15-17-34)31(36)33-27(21-37)19-26-20-32-29-9-5-4-8-28(26)29/h1-13,20,25,27,32,37H,14-19,21H2,(H,33,36)/t27-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for inhibition of Endothelin-converting enzyme 1 partially purified from porcine primary aortic endothelial cells				Bioorg Med Chem Lett 6: 619-624 (1996) Article DOI: 10.1016/0960-894X(96)00091-1 BindingDB Entry DOI: 10.7270/Q26973K3
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